In Task Manager, if you click “More details” in the bottom left corner, you can expand he view to show you, well, more details. In that view you can see percentages of your CPU, memory, hard drive and network usage. Is any of those at or near 100 %? If yes, you can rearrange the list by clicking on the particular column header (e.g. Processor) to show which processes take up the most processing power.

It may be that the game conflicts with e.g. your antivirus software (that has been known to happen), and the antivirus gets the computer stuck. In this case, you need to create an exception to your antivirus software so as not to check the Conan Exiles folder while it’s being used. How to do this depends on your antivirus software.

You can also try to close the “Not responding” conansandbox.exe by selecting it on the list and clicking the End Process button in the Task Manager. That way you don’t need to restart the whole computer.

But if no elements in the Task Manager show as overburdened, it may be something is the game installation. Is your game a Steam version? If so, you could check file integrity and see if that comes up with any errors: Right click the game on your Steam games list, select Properties, and in the Pop-up choose the Installed Files tab, and there click Verify integrity of game files. (Please note that this’ll take a lot of time, the game being the mammoth that it is.)