That usually depends on where I am and what I am planning to do. For example, if I were just adventuring and gathering around an easier biome such as the River or Jungle biome, then I would take second skin to give my character some additional carry weight. However, if I was going to be battling an enemy with a larger health pool such as Thag, or skeleton bosses in the Unnamed City, then I would take out combo master to increase the damage rate and try to shorten the duration of the fight.