If we are speaking “hypothetically”, you can prevent any creature to respawn by mods. That one playing in a PC that is doable.
A little more complicated but doable is to allow dialogue NPCs to be killed.

I would prefer another venue and remove dialogue NPCs altogether, because outlive their usefulness very quickly with mods.

But the killing in the game is not, and should not, be taken as the same thing as other environments. You are in a game universe in which it is kill or be killed, and morals are not what they are IRL. I mean, ok, it is a game, but it is a game in which you knock people out and put them on a wheel until they swear fidelity to your whims. I dont really see an argument to condemn the will to kill those who interfere with the idea you have of what you want in your World having you the power to do so. They wouldnt hesitate to kill you should they were deeming you killable.
The game files even bear aggro and killing voices for all of them. They are not meant to die, but they sure are prepared to kill should it come to that.

There should be a dynamic like Baldur’s Gate 3, you buy stuff from them, then kill them and get your money back. I mean, it is the Cashback Stygian way.

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