Strange mouse issue

I have been working on getting my side buttons on my mouse to enable sprint. I have third party software running and have remapped the side buttons for specific keys… however, every time I go into controls and try to use those mouse buttons to set them to enable sprint I get no input from them. I know they are remapped because I can see them working in notepad. Any suggestions?

addend: the side buttons keep doing autorun and I cannot seem to remap autorun to any other keys ie numpad 0.