I usually like the nano combat alien perkline more, the perk does a bit more damage and you can skimp out some IP on nano skills while levling, unless you’re going to PvP early you won’t have a need for the AR from the perkline either
As for normal perks I would make sure to have enough in Reaver for the highest damage perk you can use, if you solo a lot I would most likely opt for at least 4 points in Bio Shielding for bio cocoon. Absorbs are OP for PvM!
I personally use Training Seminar while levling for that sweet XP goodness, but if you don’t have the needed equipment to solo fast and well then it can be better to just use those perks for defensive actions.
As for weapons, you could aim for a QL 105 Panther and stick with it until 151+ where you can get a Special Edition Kyr’ozch Sword from Sector 7, once you reach Penumbra you can do the xan quest there for Blade of Khione, it’s great and you can upgrade it later on to a Blade of Khione’s Will. Really nice weapon with a stun proc that will help you out in PvM.
If you have the money you can swap out to a Kyr’Ozch Sword - Type 112 as soon as possible for higher minimum damage, Copy of the Excalibur is also a nice option with a huge damage range
Good luck and welcome back!