With how much HP allocation gives after this patch and how rebalanced the incoming damage got, consistency is pretty much an irrelevant factor now, it was already mostly irrelevant even before the patch.
Cruel Delight procs are not affected by Weapon Expertise.
With the standard 4/2 setup and at least the SA agent (to get realistic crit power values), here’s what we get for a red 20 Cruel Delight:
Crit chance: 38.1%
Crit power: 153.6%
The HPS is then equal to:
455 x 0,381 x 2,536 + 455 x 0,619 = 721 HPS
Now, you need a crit to trigger CD, which is affected by Weapon Expertise, crit chance becomes 45.6%:
721 x 0,456 = 329 HPS
With a 5/1 setup, here’s what we get:
Crit chance: 45.5%
Crit power: 109.8%
The HPS is then equal to:
455 x 0,455 x 2,098 + 455 x 0,545 = 682 HPS
Now, you need a crit to trigger CD, which is affected by Weapon Expertise, crit chance becomes 53%:
682 x 0,53 = 361 HPS
Actually, this shows the HPS is indeed better for the 5/1 setup, you were right, we’re looking at a 10% difference. With that said, if you happen to die with the 4/2 setup, the glyph setup is likely not the cause, but rather builds choices and/or gameplay, as a 10% difference in CD’s HPS should not be the determining factor of your success or failure (otherwise, you’d be basically saying that having +32 life per second is what magically saves your life in a ~13.3k HP pool? i don’t believe this much, correlation is not causality, and at best, you have a meager percentage of correlation coming from the 4/2 setup that contributes to your deaths).
Also, the other way to see it is to say that with the 4/2 setup being the superior option for DPS, you’ll require less healing in total since you’d kill your targets faster.