For off drop stuff like Demon Blood and Volatile glands, I see no difference. The reason Sickle for Salamander is the go to has nothing to do with more Volatile. It’s because that is all you get with a Sickle so you aren’t chucking 50 bags of feral on the ground.
I tend to go with Pick for demon blood but not because it works better. I just happen to multi task that job and grab gold Ore when I am up there so I have picks on me. I have used a few tools, the quality is all that impacts it. Star Metal is king right now from what I have seen.
After Frontier and pets were added a lot more mobs fit in the group of nothing special to give. Sabretooth have nothing of worth. Elk King has nothing of worth. Mammoth are strictly for Mammoth hide - skinning knife optimal, Bears are for bear pelts - skinning knife is optimal, Wolves are kind of pointless but they always were. Pigs give pork. Take that for what it’s worth - so cleaver - but in all cases, star metal gets me the most. larger scorp is the only optimal haunch source I have found, Gazelle and Goat for savory.
Back to your main general question though, off drops don’t link to a tool like hide and meat and all tools seem to yield the same numbers.