Head: Godbreaker Helmet (+3 Grit) [Master Armor Plating]
Chest: Redeemed Silent Legion Chest (+3 Strength) [Weight Reduction Kit]
Hands: Godbreaker Gauntlets (+3 Strength) [Master Armor Plating]
Legs: Guardian Legplates (+2 Strength) [Master Armor Plating]
Feet: Guardian Sabatons (+2 Strength) [Master Armor Plating]
So you end up with 37 Strength, then you eat all the special fishes that add +3 to attributes to get the 4th Strength perk (more damage on heavy hits), more HP and so on. I can’t check the armor modifications right now but I think I used Master Armor Plating for everything but the chest, I can barely carry anything and you might be able to use the weight reduction kit on more items to be able to carry more without losing too much defense.
The defense in the stats sheet is at 80% or 81% depending on whether you use reduction kits or armor plating.
My weapon is a Blade of the Adventurer with a Master Weapon Fitting.
For food I use these two items: Feast of Derketo AND Herbal Tea. Both can stack their regenration effects, they heal a lot by default already but get boosted by 100% from the vitality perk. The feast is rather expensive but the herbal tea (which is extremely strong by itself already) is very cheap. Alternatively to the feast you can use the “Hearty Stew” which is very easy to make and almost as good.
I play on 1.5 damage multiplier (NPC Damage Multiplier set to 1.5), so enemies deal 50% more damage to me and I rarely have problems facing a boss alone. With the heavy attacks of my sword I stack cripple effects so whenever I get low I can run away a few meters, eat and drink my food stuff and regenerate in basically 3 seconds from almost dead to full health.
To further add some damage I take a stack of Scorpion Queen poison with me, this stuff is extremely cumbersome to use but can add some nice damage at the beginning, in some fights (crocodile boss) you sometimes have enough time to reapply it fast enough to keep the x10 stack for longer.
The only bosses that are hard to do alone and require lots of running are the two-handed sword skeleton in the wine cellar (he basically takes half my health with a single hit), the last boss in the wine cellar (due to the adds) and the Arena Champion (is doable but still hits like a truck).
Obviously, all bosses require you to dodge and manage your stamina. You are not a tank like in Age of Conan where you can just take like 15 hits before getting critically low on health (it’s simply a different game) but with this build I am very durable, can sprint a lot (seriously, the stamina bar barely moves if you sprint) and still dodge if needed while also dealing a decent amount of damage.